RNAi
This year's Nobel Prize in Medicine is for RNAi: RNA interference. Double stranded RNA is used to silence genes. The double stranded RNA is cleaved into siRNAs (small interfering RNAs). The silencing mechanism involves additional cellular machinery that binds the siRNAs. The siRNAs then bind their target mRNA, and the mRNA is cleaved by the complex. See this nice Wiki article on the topic.
The Nobel laureates' paper appeared in Nature in 1998, so this is very recent work.
This year's Nobel Prize in Medicine is for RNAi: RNA interference. Double stranded RNA is used to silence genes. The double stranded RNA is cleaved into siRNAs (small interfering RNAs). The silencing mechanism involves additional cellular machinery that binds the siRNAs. The siRNAs then bind their target mRNA, and the mRNA is cleaved by the complex. See this nice Wiki article on the topic.
The Nobel laureates' paper appeared in Nature in 1998, so this is very recent work.
posted by LBS at 11:35 AM
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